Spain’s AI scale-up scene splits cleanly between Madrid and Barcelona, with Bilbao and Valencia each contributing a standout of their own. Madrid is home to healthcare AI, HR automation, and clinical NLP for electronic health records, while Barcelona is producing climate risk intelligence and AI security infrastructure. From federated learning platforms built for privacy-preserving AI training to AI-first phone consultation for healthcare, these are the companies proving that Spain’s AI economy is built on genuinely hard technical problems, not just applied tooling.
Companies are listed in alphabetical order. This list is non-exhaustive.
1. Crescenta
Headquarters: Madrid, Madrid, Spain | Total Funding: $21.6M | Last Funding: April 8, 2026
Private equity has historically been accessible only to institutional investors and high-net-worth individuals, leaving the broader public locked out of an asset class that has often outperformed public markets over the long run.
Crescenta offers access to investment in private equity funds to the general public through education and digitalization, opening up an asset class that used to require institutional-scale capital and connections. The company has raised $21.6 million in total funding, with its most recent round closing in April 2026, as it expands access to private equity investing for retail investors.
2. Luzia
Headquarters: Madrid, Madrid, Spain | Total Funding: $45.1M | Last Funding: May 6, 2025
Personal AI assistants have proliferated, but most are built as generic chat interfaces rather than tools designed around the actual rhythms of everyday life, from quick questions to ongoing help across the day.
Luzia is a developer of an AI-powered personal assistant designed to help in everyday life, aiming for a more integrated, day-to-day utility than a typical chatbot. The company has raised $45.1 million in total funding, with its most recent round closing in May 2025, as it continues to grow its consumer AI assistant.
3. Mitiga Solutions
Headquarters: Barcelona, Catalonia, Spain | Total Funding: $41.2M | Last Funding: February 19, 2026
Climate risk is becoming a board-level concern for insurers, governments, and large enterprises, but translating climate science into actionable, quantified risk intelligence still requires a level of scientific and computational rigor most risk teams cannot build in-house.
Mitiga Solutions provides climate risk intelligence that combines science, AI, and high-performance computing, giving organizations a more rigorous basis for pricing and managing climate exposure. The company has raised $41.2 million in total funding, with its most recent round closing in February 2026, as it expands its climate risk intelligence platform.
4. NeuralTrust
Headquarters: Barcelona, Catalonia, Spain | Total Funding: $22.9M | Last Funding: June 17, 2026
As enterprises deploy more AI agents into production, a new class of security risk has emerged: attacks, hallucinations, and data leakages specific to AI systems that conventional cybersecurity tools were never designed to catch.
NeuralTrust offers cybersecurity solutions designed to protect AI agents and applications from attacks, hallucinations, and data leakages, addressing a threat surface that has grown alongside enterprise AI adoption itself. The company has raised $22.9 million in total funding, with its most recent round closing in June 2026, as it expands its AI security platform.
5. Orbio
Headquarters: Madrid, Madrid, Spain | Total Funding: $30.1M | Last Funding: June 15, 2026
HR teams manage a process that runs from recruitment through retention, and most HR software still treats each stage as a separate system rather than a continuous relationship with the employee.
Orbio uses three AI agents, María, Daniel, and Claire, to streamline HR processes from recruitment to retention insights, treating the employee lifecycle as one continuous workflow rather than disconnected stages. The company has raised $30.1 million in total funding, with its most recent round closing in June 2026, as it grows its AI-driven HR platform.
6. Savana
Headquarters: Madrid, Madrid, Spain | Total Funding: $44.4M | Last Funding: May 13, 2025
Electronic health records contain enormous amounts of clinical detail locked away in unstructured text, information that is difficult to search, analyze, or reuse at scale using conventional database tools.
Savana focuses on electronic health records reuse, applying clinical natural language processing to unlock the clinical detail buried in unstructured medical text. The company has raised $44.4 million in total funding, with its most recent round closing in May 2025, as it expands its clinical NLP platform across health systems.
7. Shakers
Headquarters: Madrid, Madrid, Spain | Total Funding: $24.0M | Last Funding: May 13, 2025
Finding the right freelance talent for a specific project still involves a lot of manual searching, vetting, and matching, work that most companies do not have the internal recruiting capacity to do well at speed.
Shakers connects companies with freelance professionals through an AI-powered platform, automating the matching and vetting process that traditional freelance marketplaces leave largely manual. The company has raised $24 million in total funding, with its most recent round closing in May 2025, as it grows its AI-driven freelance talent platform.
8. Sherpa.ai
Headquarters: Bilbao, País Vasco, Spain | Total Funding: $47.8M | Last Funding: July 6, 2026
Training AI models on sensitive data, whether medical, financial, or personal, has long forced a tradeoff between model performance and data privacy, since the most useful training data is often the data organizations are least able to centralize or share.
Sherpa.ai bills itself as the most advanced B2B federated learning platform for privacy-preserving AI model training, letting organizations train models across distributed data without ever centralizing the underlying data itself. With $47.8 million in total funding, the highest on this list, and its most recent round closing in July 2026, Sherpa.ai continues to expand its federated learning platform.
9. Substrate AI
Headquarters: Valencia, Comunidad Valenciana, Spain | Total Funding: $44.6M | Last Funding: June 29, 2026
Applying AI effectively across genuinely different industries, from fintech to agriculture to energy, requires domain expertise that most horizontal AI platforms simply do not have built into their products.
Substrate AI offers artificial intelligence technology across fintech, agriculture, energy, human resources, and student training, building the kind of vertical-specific depth that generic AI platforms tend to lack. The company has raised $44.6 million in total funding, with its most recent round closing in June 2026, as it expands its multi-vertical AI offering.
10. Tucuvi
Headquarters: Madrid, Madrid, Spain | Total Funding: $23.9M | Last Funding: January 8, 2026
Healthcare systems struggle to keep up with the volume of routine phone consultations and follow-ups needed to monitor patients, work that consumes clinical staff time without necessarily requiring a clinician on every call.
Tucuvi is pioneering AI-first healthcare with its CE-marked platform for phone consultation automation, giving health systems a way to scale patient follow-up without scaling headcount. The company has raised $23.9 million in total funding, with its most recent round closing in January 2026, as it expands its AI-first phone consultation platform across health systems.
This was a brief overview of Spain’s rapidly expanding AI scale-up landscape. If there is a company you think belongs on this list, reach out to our editorial team and we will make sure they are included on the next one.
